Photoacoustic ocular imaging.
نویسندگان
چکیده
We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig's eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye's anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.
منابع مشابه
Photoacoustic imaging of the eye: A mini review
The eye relies on the synergistic cooperation of many different ocular components, including the cornea, crystalline lens, photoreceptors, and retinal neurons, to precisely sense visual information. Complications with a single ocular component can degrade vision and sometimes cause blindness. Immediate treatment and long-term monitoring are paramount to alleviate symptoms, restore vision, and c...
متن کاملB-Mode Photoacoustic Imaging using Linear Array: Numerical Study for Forward-Backward Minimum Variance Beamformer Combined with Delay-Multiply-and-Sum
Photoacoustic imaging (PAI) is a promising medical imaging modality which provides the resolution of Ultrasound (US) and the contrast of Optical imaging modalities. One of the most important challenges in PAI is image formation, especially in the case that a linear-array US transducer is used for data acquisition. This is due to the fact that in the linear-array scenario, there is only 60 degre...
متن کاملLabel-free photoacoustic ophthalmic angiography.
We present label-free functional photoacoustic imaging of the ocular microvasculature in living animals. The anterior segment of an adult mouse was imaged with a laser exposure level well within the American National Standards Institute safety standards. Individual red blood cells traveling along the iris capillaries were clearly resolved, and the hemoglobin oxygen saturation in the iris microv...
متن کاملHybrid-modality ocular imaging using a clinical ultrasound system and nanosecond pulsed laser.
Hybrid optical modality imaging is a special type of multimodality imaging significantly used in the recent past in order to harness the strengths of different imaging methods as well as to furnish complementary information beyond that provided by any individual method. We present a hybrid-modality imaging system based on a commercial clinical ultrasound imaging (USI) system using a linear arra...
متن کاملThe advantage of using a diode laser instead of a Q-switched laser in photoacoustic imaging of tissues
Photoacoustic (PA) imaging of biological tissues using laser diodes instead of conventional Q switched pulsed systems provides an attractive alternative for biomedical applications. However, the relatively low energy of laser diodes operating in the pulsed regime, results in generation of very weak acoustic waves, and low signal-to-noise ratio (SNR) of the detected signals. This problem can be ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Optics letters
دوره 35 3 شماره
صفحات -
تاریخ انتشار 2010